Proposal Review Criteria

Proposals are scored from 1 (unsatisfactory) to 5 (outstanding). Each component below will be scored by external reviewers and an overall priority score will also be provided.

I. Significance and Scientific Merit

How strong is the scientific premise for the project? If the aims of the project are achieved, how will the direction, progress, and thinking in relevant scientific fields be improved?

II. Appropriateness of the Proposed Method or Approach

How logical is the research approach? Does the proposed research employ innovative concepts or methods? What is the likelihood of achieving valuable results?

III. Competency of Applicant’s Personnel

Does the proposal team possess the breadth of skill/knowledge to successfully perform the proposed research? If requesting independent access and/or training, does the team adequately describe their past experience with high-resolution cryo-EM or describe their long-term training goals in sufficient detail?

IV. Sample Readiness and Reasonableness of the Proposed Resource Request

How feasible is the proposed research based on current sample readiness? If the project is in the early stages of development (i.e. the target protein not yet fully purified or optimal vitrification conditions unknown), will the proposed strategy establish feasibility benchmarks and will particularly risky aspects be managed? Are the requested instrument resources reasonable and appropriate for the proposed work?